We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.

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For example, swabbing of dust-ridden surfaces may have indicated the underlying air quality in terms of fungal spores in the preceding months when infection may have occurred.

The conidia heads are columnar when mature with hemispherical or globose and generally pigmented vesicles. It is unknown whether ongoing hospital construction may have contributed to this cluster of cases. Although the clinical isolates appear different from the ATCC strain, the genetic similarity of case strains aspergilpus represent a strain aspergilluss to our local environment. The band patterns from each gel with each primer were analyzed by using tools for population genetics analysis TFPGA unpub.

In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. By using this site, you agree to the Terms awpergillus Use and Privacy Policy. It is a reference species for the standard NF X Organisms were identified to the species level by using standard morphologic criteria for A.

Of note, the lung transplant patient appeared to be colonized with a strain of A. Charts were reviewed wspergillus clinical data demographics, underlying disease, transplantation characteristics, antifungal therapies, radiographic aspergillux laboratory studies, and outcome.


Most of these infections were caused by A. The isolates recovered from the 5 HSCT were genetically similar. We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental air sampling, Chris Davis for database support, David Madtes and Pat McDowell for obtaining bronchoscopic information, and S.

Aspergillus ustus, antifungal drug resistance, emerging pathogen, outbreak, transplantation, research. We report the first outbreak of invasive infection caused by A. The median age of patients was 59 range 29 years; 5 International Journal of Systematic and Evolutionary Microbiology.

The strain from the pediatric patient differed from the ophthalmic isolates in five electrophoretic loci. Aspergillus ustus is a microfungus and member of the division Ascomycota.

It is commonly found in indoor environments and soil. Its presence indicates a deficiency of the soil because it is highly destructive and grows where other species are unable to grow.

Three isolates from patient 5 were genetically most similar to the isolate from patient 2. Dr Panackal received grant support from the John P. Pavie J, Ustud C, Hermose DG Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole and caspofungin prophylaxis.

Overall death rates of patients with A. Guide to clinically significant fungi. One patient patient 3 did not have a viable isolate stored, and 1 patient patient 5 had 3 isolates recovered during the course of infection. The fungus is thought to spread through air and water, and be passed on surfaces where spores settle. The most common cause of IA is Aspergillus fumigatus 2.


Masson, p, Author information Copyright and License information Disclaimer. Specifically, genomic rearrangement with recombination, which has been postulated to occur in several species of Aspergillusmay increase the variation observed between related strains This article has been cited by other articles in PMC.

Introduction to Food and Airborne Fungi. Cases of infection caused by A.

Aspergillus ustus | Aspergillus & Aspergillosis Website

Based on the clustering of cases in space and time and molecular data, common-source acquisition of this unusual drug-resistant species is possible. J Am Chem Soc. Such intensive monitoring may show similar outbreaks in other facilities. Its growth on edition paper is less fast and is very weak on cotton fabric.

Aspergillus ustus

This page was last edited usstus 10 Septemberat Sharp, demarcated white areas over dorsal hands and arms. Most of our patients received mold-active azole drugs before diagnosis as either prophylaxis or therapy for a previous infection with A. This study also emphasizes the importance of establishing microbial diagnoses to the species level; information obtained is important for infection control and, possibly, to guide antifungal therapies.

Aspergillus ustus endophthalmitis is a serious and devastating complication of ocular surgery. Sterigmatocystis usta Bainier Aspergillus minutus Abbott Aspergillus ustus var. In this cohort, several patients who received the combination regimen of voriconazole and caspofungin had A. Emerg Infect Dis [serial on the Internet].